The altarpiece of the Lamentation Over the Dead Christ originally stood in the chapel of the Chair of San Pedro de Antioquia, founded by Pedro de Mutiloa at the beginning of the XVI century. This building which also contained a late-Gothic tomb and grille used to stand in the temple's former cloister that disappeared mid-XVIII century when the Virgin del Camino chapel was built. This was when the tomb of the Mutiloa family and presumably the altarpiece were relocated and placed by the portico. The altarpiece remained there until 1906, when it was once again relocated and placed in the Chapel of the Immaculate Conception where a plaque dates it as having been manufactured in the year 1506.
In 1916, the present altarpiece was made which is the reason why the Flemish altarpiece was separated from the tomb to which it had always been previously associated and when the altarpiece of Santo Cristo, a neo-Gothic work by Artieda and Arteta, made between the year 1917 and 1918, was placed where it stands today.